High Temperature Dissolved Oxygen Sensor Brings New Standard to Sterile Fermentation Monitoring

HDO100 High Temperature Dissolved Oxygen Sensor Brings New Standard to Sterile Fermentation Monitoring

In modern bioprocessing, accurate dissolved oxygen (DO) measurement is one of the most critical factors influencing cell growth, microbial activity, and product yield. Especially in pharmaceutical fermentation, enzyme production, and cell culture systems, sensors must perform reliably under extreme conditions such as high temperature, high pressure, and repeated sterilization cycles.

To meet these demanding requirements, the HDO100 High Temperature Dissolved Oxygen Sensor has been developed as a next-generation solution for high-precision and sterile bioprocess monitoring.

Engineered for Harsh Sterilization Environments

The HDO100 is specifically designed to operate under CIP (Clean-In-Place), SIP (Sterilization-In-Place), in-situ steam sterilization, and high-pressure autoclaving conditions. It can withstand temperatures of 120–130°C, ensuring stable and continuous performance throughout repeated sterilization cycles.

Unlike conventional DO electrodes that degrade under thermal stress, the HDO100 maintains structural integrity and signal stability, making it ideal for long-term industrial fermentation applications.

Ultra-Clean Design for Contamination-Free Bioprocessing

One of the key advantages of the HDO100 is its high sensor cleanliness design, which significantly reduces the risk of contamination during sensitive biological processes.

The sensor features:

• A VP connector system for secure and hygienic connection

• A 316L stainless steel full-body structure for corrosion resistance and sanitary compliance

• A precision-engineered design suitable for sterile environments

This makes it highly suitable for pharmaceutical, biotech, and food-grade fermentation systems where contamination control is critical.

Imported Membrane Cap for Stable Performance

The HDO100 is equipped with a high-quality imported membrane cap, ensuring reliable oxygen permeability and measurement stability even under harsh operating conditions.

This advanced membrane technology enables:

• Stable readings under high temperature and pressure

• Reduced signal drift during long fermentation cycles

• Extended operational lifespan in industrial environments

Reliable Performance in Long-Term Fermentation

Designed for durability, the HDO100 can withstand more than 40 fermentation batches, significantly reducing replacement frequency and maintenance costs.

Its robust construction ensures consistent performance in:

• Microbial fermentation

• Cell culture processes

• Biopharmaceutical production

• Industrial enzyme manufacturing

High Precision Measurement Capability

The sensor delivers high accuracy and fast response performance, making it suitable for real-time process control:

• Measurement range: 0–20 mg/L / 0–200% saturation

• Accuracy: ±0.3 mg/L

• Resolution: 0.01 mg/L

• Response time: <60 seconds

• Zero error: <0.1 mg/L

These specifications ensure reliable oxygen monitoring even in dynamic fermentation environments.

Flexible Integration for Bioreactor Systems

To accommodate different reactor designs, the HDO100 offers multiple installation and configuration options:

• Immersion depth options: 70 / 120 / 150 / 225 / 325 mm

• Standard thread: PG13.5

• Temperature compensation: NTC22K / PT1000 support

• Output signal: >60 nA

• Protection rating: IP68 waterproof

These features ensure seamless integration with modern bioreactor and fermentation systems.

Advancing the Future of Dissolved Oxygen Monitoring

As bioprocess industries continue to move toward higher efficiency, stricter sterility, and real-time process control, the demand for robust and intelligent sensors continues to grow.

The HDO100 High Temperature Dissolved Oxygen Sensor represents a significant step forward in DO measurement technology, combining high-temperature resistance, ultra-clean design, long service life, and industrial-grade reliability.

It is not just a sensor—it is a critical tool for improving process stability, increasing yield, and ensuring consistent product quality in advanced biomanufacturing systems.